Associate Professor
Satyavrata Samavedi
CHE-409
···
Research Lab: CHE-321
PhD: Ph.D, Virginia Tech, Blacksburg
Research Interests: Polymeric biomaterials, Electrospinning, Controlled drug/protein release, Co-amorphous formulations, Combination therapy, Immunomodulation
Polymeric Biomaterials & Pharmaceutical Soft Matter: Bridging Process, Structure, Properties and Performance
Research Overview
The ECM Lab at IIT Hyderabad pursues problems in the domains of polymeric biomaterials and pharmaceutical soft matter. We investigate process-structure-property relations in polymers with the goal of employing them in drug carrier design. A major focus in our lab is electrospinning, which we holistically investigate to gain insights into fiber and particle formation. We use this understanding to design amoprhous solid dispersions for the loading and regulated release of poorly soluble drugs. We study the physics of electrospinning, investigate the thermodynamic properties of drug-polymer systems, elucidate drug release mechanisms and engineer technologies for the concurrent co-release of multiple therapeutics. In close collaboration with biologists, we deploy drug-loaded materials to target chronic inflammation. More recently, we have begun taking an active interest in investigating co-amorphous drug mixtures, with specific reference to molecular interactions that govern their glass transition and physical stability.
Research Highlights
Electrospinning physics and design of fibrous meshes
We investigate polymer electrospinning via direct in situ visualization of the cone/jet to gain insights into parameters that influence jet initiation/stretching. Here, we are interested in understanding the complex interplay between several competing forces that dictate cone/jet dynamics and eventually control fiber formation. These insights are used to develop fibrous meshes with predictable properties.
Amorphous drug carriers and (co)-amorphous mixtures
We adopt a fundamental approach to understanding the roles of matrix properties that govern the release of poorly soluble drugs. We build upon this knowledge to design polymer-based carriers that exhibit controlled release of drugs, particularly zero-order kinetics. A growing interest in our group is to uncover rules governing the physical stability of co-amorphpous drug mixtures, with reference to their glass transition temperature.
Therapeutic biomaterials for combination therapy
We engineer new technologies to process polymers and create biomaterial composites that can simultaneously deliver multiple drugs and/or cytokines while retaining independent control over release of the individual therapeutics and preserving biological functionality. In collaboration with biologists, we deploy such materials to target dysfunctional immune responses associated with degenerative diseases.
Selected Publications
A robust truncated-domain approach for cone–jet simulations in electrospinning and electrospraying
Ghanashyam K. C., Satyavrata Samavedi, and Harish N. Dixit
Voices in Molecular Pharmaceutics: Meet Professor Satyavrata Samavedi
Satyavrata Samavedi
Leveraging molecular interactions to develop design framework for coamorphous drug–drug mixtures
Dani Lakshman Yarlagadda; Kohsaku Kawakami; Satyavrata Samavedi
Connecting in situ cone/jet length in electrospinning to fiber diameter and drug release for the rational design of electrospun drug carriers
Nikhita Joy; Dhivya Venugopal; Anu M Gopinath; Satyavrata Samavedi
Establishment of Unique Cone Shapes and Universal Shape Parameters toward Predicting Fiber Diameter in Polymer Electrospinning
Swasthika Arunachalam; Harish N Dixit; Satyavrata Samavedi
Evaluating the protective effects of dexamethasone and electrospun mesh combination on primary human mixed retinal cells under hyperglycemic stress
Dhivya Venugopal; Sushma Vishwakarma; Neha Sharma; Inderjeet Kaur; Satyavrata Samavedi
Electrospun fiber-based strategies for controlling early innate immune cell responses: Towards immunomodulatory mesh designs that facilitate robust tissue repair
Venugopal, D.; Vishwakarma, S.; Kaur, I.; Samavedi, S.
Particle-based vehicles for growth factor delivery from electrospun meshes
Shaw G. S.; Samavedi S.
Strategies for tunable drug release from electrospun composites
Joy N.; Venugopal D.; Samavedi S.
Coupling between voltage and tip-to-collector distance in polymer electrospinning: Insights from analysis of regimes, transitions and cone/jet features
Joy, N.; Anuraj, R.; Viravalli, A.; Dixit, H. N.; Samavedi, S.