Satyavrata Samavedi

Ph.D, Virginia Tech, Blacksburg

Associate Professor, Chemical Engineering

Email:   samavedi[at]che.iith.ac.in

Office:  A-409         Lab:  A-321

Tel:  040-2301--6216

Areas of Interest:  Polymeric biomaterials, Electrospinning, Controlled drug/protein release, Co-amorphous formulations, Combination therapy, Immunomodulation

“The design, processing and functionalization of degradable biomaterial matrices: from polymer physics to biomedical applications.”

The Electrospun Cellular Microenvironments (ECM) Laboratory is interested in investigating structure-property-processing relationships in polymeric biomaterials for biomedical applications. We study and control the process of electrospinning to rationally design functional polymeric matrices for promoting controlled drug release, creating stable amorphous drug formulations and achieving drug/cytokine combination therapy for immunomodulation.

Research Areas

1. Physics of polymer electrospinning: We investigate electrospinning via direct in situ visualization of the cone/jet to gain insights into parameters that influence cone dynamics, jet initiation/stretching and fiber formation. These insights are used to develop fibrous meshes with predictable diameter and specific mesh properties.

2. Design of controlled release carriers: We adopt a fundamental approach to understanding the roles of matrix properties that govern the release of small molecule hydrophobic drugs. We build upon this knowledge to design carriers that exhibit controlled and sustained release of immunomodulatory drugs, particularly zero-order kinetics. A growing interest in our group is the development of stable co-amorphous drug formulations.

3. Combination therapy for immunomodulation: We develop technologies to process polymers that can simultaneously deliver drugs and proteins while retaining independent control over release of the individual therapeutics and preserving biological functionality. In close collaboration with biologists, we currently target dysfunctional macrophage responses associated with degenerative diseases.

Selected Publications

1. N Joy, “Coupling between voltage and tip-to-collector distance in polymer electrospinning: insights from analysis of regimes, transitions & cone/jet features”, Chemical Engineering Science, 230, 116200, 2021.

2. D Venugopal et al., “Electrospun meshes intrinsically promote M2 polarization of microglia under hypoxia and offer protection from hypoxia-driven cell death”, Biomedical Materials, 16, 045049, 2021

3. N Joy et al., "Robust strategies to reduce burst and achieve tunable control over extended drug release from uniaxially electrospun composites", European Polymer Journal, 168, 111102, 2022 .

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